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New strategies in synthesis of acyclic nucleoside phosphonate prodrugs
- 1.0361376 - ÚOCHB 2012 CZ eng C - Conference Paper (international conference)
Krečmerová, Marcela - Tichý, Tomáš - Blažek, Jiří - Pomeisl, Karel
New strategies in synthesis of acyclic nucleoside phosphonate prodrugs.
Chemistry of Nucleic Acid Components. 15th Symposium. Praha: Institute of Organic Chemistry and Biochemistry AS CR, v. v. i., 2011 - (Hocek, M.), s. 163-166. Collection Symposium Series, 12. ISBN 978-80-86241-37-1.
[Chemistry of Nucleic Acid Components /15./. Český Krumlov (CZ), 05.06.2011-10.06.2011]
R&D Projects: GA MŠMT 1M0508
Grant - others:NIH(US) 1UC1 AI062540-01
Institutional research plan: CEZ:AV0Z40550506
Keywords : ester prodrugs * ANP * HATU * phophonates * PyBOP * PyBroP * glycosylation
Subject RIV: CC - Organic Chemistry
New syntheses of acyclic nucleoside phosphonate prodrugs including dioxolenone derivatives, functionalized alkoxyalkyl esters, utilization of hexafluorophosphate coupling agents and enzymatic glycosylations were described. Comparison of antiviral activities of diverse prodrugs was performed.
Permanent Link: http://hdl.handle.net/11104/0198699
Number of the records: 1