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Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: Efficient synthesis and antiviral activity
- 1.0361235 - ÚOCHB 2012 RIV GB eng J - Journal Article
Hocková, Dana - Holý, Antonín - Andrei, G. - Snoeck, R. - Balzarini, J.
Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: Efficient synthesis and antiviral activity.
Bioorganic & Medicinal Chemistry. Roč. 19, č. 15 (2011), s. 4445-4453. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA MŠMT 1M0508; GA ČR GAP207/11/0108
Institutional research plan: CEZ:AV0Z40550506
Keywords : drug design * purines * pyrimidines
Subject RIV: CC - Organic Chemistry
Impact factor: 2.921, year: 2011
Series of novel acyclic nucleoside phosphonates with various nucleobases and 2-(2-phosphonoethoxy)ethyl chain bearing various substituents in beta-position to the phosphonate moiety were prepared. The influence of structural alternations on antiviral activity was studied.
Permanent Link: http://hdl.handle.net/11104/0198597
Number of the records: 1