Number of the records: 1
Chemical synthesis of prodrugs derived from 5,6-dihydro-5-azacytosine and its nucleosides using vinyl esters
- 1.0361138 - ÚOCHB 2012 CZ eng C - Conference Paper (international conference)
Janská, Lucie - Blažek, Jiří - Mařák, David - Otmar, Miroslav - Krečmerová, Marcela
Chemical synthesis of prodrugs derived from 5,6-dihydro-5-azacytosine and its nucleosides using vinyl esters.
Chemistry of Nucleic Acid Components. 15th Symposium. Praha: Institute of Organic Chemistry and Biochemistry AS CR, v. v. i., 2011 - (Hocek, M.), s. 349-350. Collection Symposium Series, 12. ISBN 978-80-86241-37-1.
[Chemistry of Nucleic Acid Components /15./. Český Krumlov (CZ), 05.06.2011-10.06.2011]
R&D Projects: GA MŠMT 1M0508
Institutional research plan: CEZ:AV0Z40550506
Keywords : amide prodrugs * 5,6-dihydro-5-azacytosine * vinyl esters
Subject RIV: CC - Organic Chemistry
New strategy for synthesis of amide prodrugs without protecting groups for 5,6-dihydro-5-azacytosine and its nucleosides was developed and introduced. Vinyl esters were used as acyl donor and the reactive amino group on the heterocycle functions as nucleophile.
Permanent Link: http://hdl.handle.net/11104/0198532
Number of the records: 1