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Polysaccharides in Medicinal and Pharmaceutical Applications
- 1.0361112 - ÚOCHB 2012 RIV GB eng M - Monography Chapter
Šebestík, Jaroslav - Reiniš, Milan - Ježek, Jan
Carbohydrate-Containing Dendrimers in Biomedical Applications.
Polysaccharides in Medicinal and Pharmaceutical Applications. Shawbury: iSmithers, 2011 - (Popa, V.), s. 353-384. ISBN 978-1-84735-437-2
R&D Projects: GA ČR GA203/07/1517; GA AV ČR IAA400550702
Grant - others:AV ČR(CZ) M200550902
Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50520514
Keywords : dendrimers * drug delivery * gene delivery * glycobiology * glycoclusters
Subject RIV: CC - Organic Chemistry
http://www.ismithers.net
Glycodendrimers are (regularly) branched structures containing carbohydrates. Many of these compounds with various composition and structure are mentioned; as well as, their practical applications spanning from drug and gene deliveries, synthetic vaccines, prevention of pathological processes caused by bacteria and viruses, etc. A dendrimeric state, physicochemical properties of dendrimers, and general consequences are reviewed with emphasis to a cluster effect and multivalency. Two main approaches of glycodendrimer syntheses - convergent and divergent - are described. Since glycopeptide dendrimers suppress lectin-carbohydrate interactions, glycodendrimeric libraries provide potent inhibitors of bacterial adhesion and biofilm formation.
Permanent Link: http://hdl.handle.net/11104/0198516
Number of the records: 1