Synthesis of conformationally locked carbocyclic nucleosides with norbornane as pseudosugar moiety

0360803 - ÚOCHB 2012 CZ eng C - Conference Paper (international conference)
Dejmek, Milan - Hřebabecký, Hubert - Šála, Michal - Dračínský, Martin - Nencka, Radim
Synthesis of conformationally locked carbocyclic nucleosides with norbornane as pseudosugar moiety.
Chemistry of Nucleic Acid Components. 15th Symposium. Praha: Institute of Organic Chemistry and Biochemistry AS CR, v. v. i., 2011 - (Hocek, M.), s. 208-215. Collection Symposium Series, 12. ISBN 978-80-86241-37-1.
[Chemistry of Nucleic Acid Components /15./. Český Krumlov (CZ), 05.06.2011-10.06.2011]
R&D Projects: GA MŠMT 1M0508
Institutional research plan: CEZ:AV0Z40550506
Keywords : norbornane * conformationally locked cyrbocyclic nucleosides
Subject RIV: CC - Organic Chemistry

We describe the chemical synthesis of three novel structural types of conformationally locked carbocyclic nucleosides with norbornane as sugar surrogate. The presented structures bear hydroxymethyl, nucleobase or both in the bridgehead positions of the norbornane pseudosugar and thus adopt three different conformations of the cyclopentane ring – North, South, and East.
Permanent Link: http://hdl.handle.net/11104/0198268