Results and Problems in Cell Differentiation

0360511 - ÚŽFG 2012 RIV DE eng M - Monography Chapter
Kalab, P. - Šolc, Petr - Motlík, Jan
The Role of RanGTP Gradient in Vertebrate Oocyte Maturation.
Results and Problems in Cell Differentiation. Heidelberg: Springer, 2011, s. 235-267. ISBN 978-3-642-19065-0
R&D Projects: GA ČR(CZ) GC301/09/J036; GA MŠMT ME08030
Institutional research plan: CEZ:AV0Z50450515
Keywords : RanGTP * Oocyte
Subject RIV: EB - Genetics ; Molecular Biology
http://www.springerlink.com/content/qk17263h12g7m477/

The maturation of vertebrate oocyte into haploid gamete, the egg, consists of two specialized asymmetric cell divisions with no intervening S-phase. Ran GTPase has an essential role in relaying the active role of chromosomes in their own segregation by the meiotic process. In addition to its conserved role as a key regulator of macromolecular transport between nucleus and cytoplasm, Ran has important functions during cell division, including in mitotic spindle assembly and in the assembly of nuclear envelope at the exit from mitosis. The cellular functions of Ran are mediated by RanGTP interactions with nuclear transport receptors (NTRs) related to importin b and depend on the existence of chromosome-centered RanGTP gradient. Live imaging with FRET biosensors indeed revealed the existence of RanGTP gradient throughout mouse oocyte maturation.
Permanent Link: http://hdl.handle.net/11104/0198038