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Astroglial networks scale synaptic activity and plasticity
- 1.0359930 - ÚEM 2012 RIV US eng J - Journal Article
Pannasch, U. - Vargová, Lýdia - Reingruber, J. - Ezan, P. - Holcman, D. - Giaume, C. - Syková, Eva - Rouach, N.
Astroglial networks scale synaptic activity and plasticity.
Proceedings of the National Academy of Sciences of the United States of America. Roč. 108, č. 20 (2011), s. 8467-8472. ISSN 0027-8424. E-ISSN 1091-6490
R&D Projects: GA MŠMT(CZ) MEB021140
Grant - others:GA MŠk(CZ) 1M0538
Program: 1M
Institutional research plan: CEZ:AV0Z50390512
Keywords : hippocampus * neuroglial interactions
Subject RIV: FH - Neurology
Impact factor: 9.681, year: 2011
Using mice deficient for connexin 30 and 43, the study show that astroglial networks tone down hippocampal synaptic transmission in CA1 pyramidal neurons. Gap junctional networking facilitates extracellular glutamate and potassium removal during synaptic activity through modulation of astroglial clearance rate and extracellular space volume. By controlling synaptic strength, connexins play an important role in synaptic plasticity. The results establish connexins as critical proteins for extracellular homeostasis, important for the formation of functional synapses.
Permanent Link: http://hdl.handle.net/11104/0197610
Number of the records: 1