Flt3 ligand synergizes with granulocyte-colony-stimulating factor in bone marrow mobilization to improve functional outcome after spinal cord injury in the rat

0359902 - ÚEM 2012 RIV GB eng J - Journal Article
Machová-Urdzíková, Lucia - Mašínová, Katarína - Vaněček, Václav - Růžička, Jiří - Šedý, Jiří - Syková, Eva - Jendelová, Pavla
Flt3 ligand synergizes with granulocyte-colony-stimulating factor in bone marrow mobilization to improve functional outcome after spinal cord injury in the rat.
Cytotherapy. Roč. 13, č. 9 (2011), s. 1090-1104. ISSN 1465-3249. E-ISSN 1477-2566
R&D Projects: GA AV ČR IAA500390902; GA MŠMT(CZ) LC554
Grant - others:GA MŠk(CZ) 1M0538
Program: 1M
Institutional research plan: CEZ:AV0Z50390703
Keywords : axonal sprouting * bone marrow mobilization * Flt3 ligand
Subject RIV: FH - Neurology
Impact factor: 3.627, year: 2011

The aim of this study was to evaluate the effect of G-CSF and/or the Flt3 ligand on functional outcome and tissue regeneration in a rat model of spinal cord injury (SCI). Rats with a balloon-induced compression lesion were injected with G-CSF and/or Flt3 ligand to mobilize bone marrow cells. Behavioral tests, blood counts, morphometric evaluation of the white and gray matter, and histology were performed 5 weeks after SCI.Our results showed, that the mobilization of bone marrow cells by G-CSF, Flt3 ligand and particularly their combination improved the motor and sensory performance of rats with SCI, reduced glial scarring, increased axonal sprouting and spared white and gray matter in the lesion.
Permanent Link: http://hdl.handle.net/11104/0197593