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Immunocytochemical demonstration of M1 muscarinic acetylcholine receptors at the presynaptic and postsynaptic membranes of rat diaphragm endplates
- 1.0359261 - FGÚ 2012 RIV CZ eng J - Journal Article
Malomouzh, A. I. - Arkhipova, S. S. - Nikolsky, E. E. - Vyskočil, František
Immunocytochemical demonstration of M1 muscarinic acetylcholine receptors at the presynaptic and postsynaptic membranes of rat diaphragm endplates.
Physiological Research. Roč. 60, č. 1 (2011), s. 185-188. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA AV ČR(CZ) IAA500110905; GA ČR GA202/09/0806
Institutional research plan: CEZ:AV0Z50110509
Keywords : skeletal muscle * M1 muscarinic receptor
Subject RIV: ED - Physiology
Impact factor: 1.555, year: 2011
M1-muscarinic acetylcholine (ACh) receptors (M1R) were directly demonstrated immunocytochemically in electronmicroscopic images of rat diaphragm neuromuscular junctions (NMJ). Specific electron-dense granules were located at presynaptic nerve ending membranes and in the sarcolemma in the depths of postsynaptic folds. This first visualization of M1R on both sides of the NMJ is in agreement with previous pharmacological data on the regulatory role of M1R in quantal and non-quantal ACh release
Permanent Link: http://hdl.handle.net/11104/0197075
Number of the records: 1