Oostatic peptides containing D-amino acids: Degradation, accumulation in ovaries and NMR-study

0356842 - ÚOCHB 2011 DK eng C - Conference Paper (international conference)
Hlaváček, Jan - Bennettová, Blanka - Černý, Bohuslav - Vlasáková, Věra - Holík, Josef - Buděšínský, Miloš - Slaninová, Jiřina - Tykva, Richard … Total 9 authors
Oostatic peptides containing D-amino acids: Degradation, accumulation in ovaries and NMR-study.
Peptides 2010: Tales of Peptides. Proceedings of the Thirty-First European Peptide Symposium. Copenhagen: European Peptide Society, 2010 - (Lebl, M.; Meldal, M.; Jensen, K.; Hoeg-Jensen, T.), s. 590-591. ISBN 0-9715560-5-9.
[Peptides 2010: Tales of Peptides. Proceedings of the European Peptide Symposium /31./. Copenhagen (DK), 05.09.2010-09.09.2010]
R&D Projects: GA ČR GA203/06/1272
Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50380511
Keywords : oostatic peptides * D-amino acids * NMR
Subject RIV: CC - Organic Chemistry

The D-amino acid containing pentapeptides exhibit high oostatic effect in the flesh fly Neobellieria bullata and significantly delayed incorporation of radioactivity from their tritiated forms to insect ovaries. The decreased enzymatic degradation of the peptide bonds neighboring with the D-amino acid residues prolongs half-life of the corresponding pentapeptides, which can thus affect more ovarian cells.
Permanent Link: http://hdl.handle.net/11104/0195259