STIM1-Directed Reorganization of Microtubules in Activated Mast Cells

0355825 - ÚMG 2011 RIV US eng J - Journal Article
Hájková, Zuzana - Bugajev, Viktor - Dráberová, Eduarda - Vinopal, Stanislav - Dráberová, Lubica - Janáček, Jiří - Dráber, Petr - Dráber, Pavel
STIM1-Directed Reorganization of Microtubules in Activated Mast Cells.
Journal of Immunology. Roč. 186, č. 2 (2011), s. 913-923. ISSN 0022-1767. E-ISSN 1550-6606
R&D Projects: GA ČR(CZ) GD204/09/H084; GA ČR GA204/09/1777; GA ČR GA301/09/1826; GA ČR GAP302/10/1759; GA MŠMT LC545; GA MŠMT(CZ) LC06063; GA AV ČR KAN200520701
Institutional research plan: CEZ:AV0Z50520514; CEZ:AV0Z50110509
Keywords : STIM1 * bonemarrow-derived mast cells * microtubules
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 5.788, year: 2011

This research article shows important role of STIM1 protein in activation of bone marrow-derived mast cells. During activation process, mast cells change intracellular level of calcium and present microtubule reorganization. The molecular mechanisms for control microtubule rearrangement during activation events are still unknown. Activation of mast cells results in generation of microtubule protrusions that are calcium dependent. Experiments with knockdown or reexpression of STIM1 protein, the key regulator of store-operated calcium entry, confirmed the important role of STIM1 in the formation of protrusions. This article propose that calcium plays an important role in the formation of microtubule protrusions in mast cells and that rearrangement of microtubules in activated mast cells depends on STIM1-induced calcium entry.
Permanent Link: http://hdl.handle.net/11104/0194505