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Cyanide inhibition and pyruvate-induced recovery of cytochrome c oxidase
- 1.0355550 - FGÚ 2011 RIV US eng J - Journal Article
Nůsková, Hana - Vrbacký, Marek - Drahota, Zdeněk - Houštěk, Josef
Cyanide inhibition and pyruvate-induced recovery of cytochrome c oxidase.
Journal of Bioenergetics and Biomembranes. Roč. 42, č. 5 (2010), s. 395-403. ISSN 0145-479X. E-ISSN 1573-6881
R&D Projects: GA ČR(CZ) GA303/07/0781; GA MŠMT(CZ) 1M0520; GA MŠMT OC08017
Institutional research plan: CEZ:AV0Z50110509
Keywords : cytochrom c oxidase * cyanide * oxygen affinity
Subject RIV: CE - Biochemistry
Impact factor: 3.637, year: 2010
Analysis of the mechanism of cyanide inhibitory effect on the mitochondrial cytochrome c oxidase demonstrates that the inhibition of COX by cyanide is fully reversible but the potential of pyruvate as a cyanide poisoning antidote is limited. COX affinity for oxygen is the most sensitive indicator of cyanide toxic effects
Permanent Link: http://hdl.handle.net/11104/0194296
Number of the records: 1