HIF1 Pathways in Diabetic Embryopathy

0355319 - BTÚ 2011 US eng C - Conference Paper (international conference)
Pavlínková, Gabriela - Bohuslavová, Romana - Kuthanová, Lada - Salbaum, M. - Kappen, C.
HIF1 Pathways in Diabetic Embryopathy.
Hypoxia: Molecular mechanisms of Oxygen Sensing and Response Pathways. Colorado: Keystone Resort, 2010, s. 99-99.
[Keystone Symposia on Molecular and Cellular Biology. Colorado (US), 19.01.2010-24.01.2010]
Institutional research plan: CEZ:AV0Z50520701
Keywords : diabetic embryopathy
Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition

Maternal diabetes negatively affects the normal embryonic development causing diabetic embryopathy in humans. The most prominent congenital malformations associated with diabetic embryopathy are neural tube defects, cardiovascular defects, and caudal dysgenessis. Using the mouse as an experimental system and global gene expression profiling, we have found that altered transcriptional regulation plays a major role in the response of embryos to intrauterine exposure to diabetic conditions. One of the diabetes-deregulated transcription factors was Hypoxia inducible factor 1 alpha (Hif1α). In addition, the expression of 22 known HIF1 target genes was significantly altered in diabetes-exposed embryos compared to controls. The critical role of Hif1α pathways in embryonic development was demonstrated by the Hif1α homozygous null mutation. Hif1α-/- knockout embryos die around midgestation because of severe cardiovascular and neural tube defects
Permanent Link: http://hdl.handle.net/11104/0194120