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The expanded CD19+IgM+CD27-CD21lowCD38lowCD24- B cell population in CVID patients shows the signs of antigen-driven selection and affinity maturation
- 1.0355243 - BTÚ 2011 eng C - Conference Paper (international conference)
Růžičková, Šárka - Nováková, L. - Vlková, M. - Kalina, T. - Janda, A. - Šedivá, A. - Litzman, J.
The expanded CD19+IgM+CD27-CD21lowCD38lowCD24- B cell population in CVID patients shows the signs of antigen-driven selection and affinity maturation.
Abstracts of 2nd European Congress of Immunology, Immunity for Life, Immunity for Health. Wiley-Blackwell, 2009, ---. ISSN 0014-2980. E-ISSN 1521-4141.
[2nd European Congress of Immunology: Immunity for Life, Immunity for Health. Berlín (DE), 13.09.2009 – 16.09. 2009]
Institutional research plan: CEZ:AV0Z50520701
Keywords : single-cell RT-PCR * , mutational frequency * somatic hypermutation
Subject RIV: EC - Immunology
: New CD21-CD38-CD27-CD24+IgM+ and CD21-CD38- CD27-CD24-IgM+ subpopulations of B lymphocytes were shown using molecular analysis to display the signs of antigen-driven selection, affinity maturation and isotype switching in both patients with immunodeficiences and controls. Thus, they might represent a new so far undescribed type of unconventional (non-classical) B lymphovytes likely playing more general role in B cell homeostasis
Permanent Link: http://hdl.handle.net/11104/0194059
Number of the records: 1