Use of I-125-labeled iodothyronines as tools for studies of Fluoxetine interaction with the metabolism of triiodothyronine

0354750 - FGÚ 2011 IN eng C - Conference Paper (international conference)
Pavelka, Stanislav
Use of I-125-labeled iodothyronines as tools for studies of Fluoxetine interaction with the metabolism of triiodothyronine.
Application of Radiotracers in Chemical, Environmental and Biological Sciences. Vol.3. Kolkata: Saha Institute of Nuclear Physics, 2010 - (Lahiri, S.; Maiti, M.; Das, S.), s. 345-347. ISSN 0973-256X.
[Application of Radiotracers in Chemical, Environmental and Biological Sciences. Kolkata (IN), 07.11.2010-13.11.2010]
R&D Projects: GA ČR(CZ) GA304/08/0256
Institutional research plan: CEZ:AV0Z50110509
Keywords : fluoxetine * I-125-labeled iodothyronines * triiodothyronine
Subject RIV: FR - Pharmacology ; Medidal Chemistry

In studies of the interaction of an antidepressant drug fluoxetine with the metabolism of thyroid hormones in the rat, we applied adapted radiometric enzyme assays for iodothyronine sulfotransferases and uridine 5-diphospho-glucuronyltransferase, as well as our newly developed radiometric assays for iodothyronine deiodinases of types 1, 2 and 3, using [I-125]-labeled iodothyronines as substrates
Permanent Link: http://hdl.handle.net/11104/0006276