HPMA-based polymer therapeutics improve the efficacy of surgery, of radiotherapy and of chemotherapy combinations

0354076 - ÚMCH 2011 GB eng J - Journal Article
Lammers, T. - Šubr, Vladimír - Ulbrich, Karel - Peschke, P. - Huber, P. E. - Hennink, W. E. - Storm, G. - Kiessling, F.
HPMA-based polymer therapeutics improve the efficacy of surgery, of radiotherapy and of chemotherapy combinations.
Nanomedicine. Roč. 5, č. 10 (2010), s. 1501-1523. ISSN 1743-5889. E-ISSN 1748-6963
R&D Projects: GA MŠMT 1M0505
Institutional research plan: CEZ:AV0Z40500505
Keywords : N-(2-hydroxypropyl)methacrylamide copolymers * nanomedicine * drug delivery
Subject RIV: EI - Biotechnology ; Bionics
Impact factor: 6.202, year: 2010

To broaden the clinical applicability of tumor-targeted nanomedicines we have developed several concepts for using N-(2-hydroxypropyl)methacrylamide (HPMA)-based polymer therapeutics to enhance the efficacy of combined modality anticancer therapy. Regarding surgery, HPMA copolymers were shown to be able to improve the retention of intratumorally administered chemotherapeutic agents at the pathological site, and increase their therapeutic index. Synergistic interaction was observed with radiotherapy improving the tumor accumulation of the copolymers, and improving both the efficacy and the tolerability of radiochemotherapy. Regarding chemotherapy combinations, we have provided in vivo evidence showing that passively tumor-targeted polymeric drug carriers can be used to deliver two different drugs to tumors simultaneously. Based on these findings, we conclude that nanomedicine formulations are highly suitable systems for improving the efficacy of combined modality anticancer therapy.
Permanent Link: http://hdl.handle.net/11104/0006251