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Synthesis of new potential inhibitors of 5´-nucleotidases
- 1.0353436 - ÚOCHB 2011 FR eng C - Conference Paper (international conference)
Šimák, Ondřej - Buděšínský, Miloš - Petrová, Magdalena - Zborníková, Eva - Pachl, Petr - Brynda, Jiří - Rosenberg, Ivan
Synthesis of new potential inhibitors of 5´-nucleotidases.
International Roundtable on Nucleosides, Nucleotides and Nucleic Acids. IRT 2010. Lyon: Université de Lyon, 2010, s. 328-329.
[International Roundtable on Nucleosides, Nucleotides and Nucleic Acids. IRT 2010. Lyon (FR), 29.08.2010-03.09.2010]
R&D Projects: GA MŠMT(CZ) LC06077; GA AV ČR KAN200520801; GA ČR GA203/09/0820
Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50520514
Keywords : nucleoside phosphonic acids * 5'-nucleosidase inhibitor * 5-phosphonoalkyl nucleoside
Subject RIV: CC - Organic Chemistry
http://irt2010.univ-lyon1.fr
Isopolar non-isosteric phosphonate analogue of 3´-deoxy-3´,4´-didehydronucleoside 5´-phosphates was prepared and converted to diphosphoryl derivative. The obtained 5´-triphosphate analogue was checked as substrate for HCV RNA-dependent RNA polymerase.
Permanent Link: http://hdl.handle.net/11104/0192687
Number of the records: 1