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Novel isopolar non-isosteric phosphonate analogues of 3´-deoxy-3´,4´-didehydronucleoside 5´-phosphates
- 1.0353427 - ÚOCHB 2011 FR eng C - Conference Paper (international conference)
Petrová, Magdalena - Buděšínský, Miloš - Rosenberg, Ivan
Novel isopolar non-isosteric phosphonate analogues of 3´-deoxy-3´,4´-didehydronucleoside 5´-phosphates.
International Roundtable on Nucleosides, Nucleotides and Nucleic Acids. IRT 2010. Lyon: Université de Lyon, 2010, s. 311-312.
[International Roundtable on Nucleosides, Nucleotides and Nucleic Acids. IRT 2010. Lyon (FR), 29.08.2010-03.09.2010]
R&D Projects: GA MŠMT(CZ) LC06077; GA MŠMT(CZ) LC06061; GA ČR GA202/09/0193
Institutional research plan: CEZ:AV0Z40550506
Keywords : phosphonate analog * triphosphate analog * didehydronucleoside
Subject RIV: CC - Organic Chemistry
http://irt2010.univ-lyon1.fr
Isopolar non-isosteric phosphonate analogue of 3´-deoxy-3´,4´-didehydronucleoside 5´-phosphates was prepared and converted to diphosphoryl derivative. The obtained 5´-triphosphate analogue was checked as substrate for HCV RNA-dependent RNA polymerase.
Permanent Link: http://hdl.handle.net/11104/0192679
Number of the records: 1