Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use

0349828 - ÚEB 2011 RIV DE eng P - Patent Document
Moravcová, Daniela - Havlíček, Libor - Kryštof, Vladimír - Lenobel, René - Binarová, Pavla - Mlejnek, P. - Vojtešek, B. - Uldrijan, S. - Schmülling, T. - Strnad, Miroslav
Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use.
Mnichov: European patent office, 2010. Owner: Ústav experimentální botaniky AV ČR, v. v. i., Univerzita Palackého v Olomouci. Date of the patent registration: 06.05.2003. Date of the patent acceptance: 28.07.2010. Patent Number: EP1475094
R&D Projects: GA ČR GA301/08/1649; GA ČR GA522/09/1576
Keywords : disubstituted pyrazolo[4,3-d]pyrimidine * cancer therapy * agricultural practice
Subject RIV: FD - Oncology ; Hematology
http://v3.espacenet.com/publicationDetails/originalDocument?FT=D&date=20100728&DB=EPODOC&locale=en_EP&CC=EP&NR=1475094B1&KC=B1 http://arl-repository.lib.cas.cz/uloziste_av/UEB-Q/cav_un_epca-0349828_01.pdf

This invention relates to new disubstituted pyrazolo[4,3-d]pyrimidine derivatives and to their use in suitable utilities, especially in cancer therapy and agricultural practice. The compounds are antimitotic, anticancer, herbicidal, fungicidal and insecticidal having improved selectivity and efficiency index, i.e. that are less toxic yet more efficacious than analogues known. It is an object of this invention to provide 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines, which inhibit the cdks, cell proliferation, and/or induce apoptosis. A further object of the invention is to provide a method for inhibiting cell proliferation and inflammatory diseases to a mammal in need of an effective amount 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines.The solution of this object are 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines of the formula I.
Permanent Link: http://hdl.handle.net/11104/0189968