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Serotonin fibre sprouting and increase in serotonin transporter immunoreactivity in the CA1 area of hippocampus in a triple transgenic mouse model of Alzheimer's disease
- 1.0349468 - ÚEM 2011 RIV GB eng J - Journal Article
Noristani, H. N. - Olabarria, M. - Verkhratsky, Alexei - Rodríguez Arellano, Jose Julio
Serotonin fibre sprouting and increase in serotonin transporter immunoreactivity in the CA1 area of hippocampus in a triple transgenic mouse model of Alzheimer's disease.
European Journal of Neuroscience. Roč. 32, č. 1 (2010), s. 71-79. ISSN 0953-816X. E-ISSN 1460-9568
R&D Projects: GA ČR GA309/09/1696; GA ČR GA305/08/1384
Institutional research plan: CEZ:AV0Z50390703
Keywords : Alzheimer's disease * hippocampus * plasticity
Subject RIV: FH - Neurology
Impact factor: 3.658, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0349468_01.pdf
In this work, we studied the hippocampal 5-HT innervation during the progression of Alzheimer’s disease in a triple transgenic mouse model of Alzheimer’s disease; which mimics the spatio-temporal and cognitive evolution of the disease. We observed a biphasic increase in serotonin transporter fibres in transgenic animals at 3 months and at 18 months of age; suggesting that this modifications imply a 5-HT sprouting, which may account for imbalanced serotonergic neurotransmission associated with Alzheimer’s disease cognitive impairment.
Permanent Link: http://hdl.handle.net/11104/0189701
Number of the records: 1