Bral1: Its Role in Diffusion Barrier Formation and Conduction Velocity in the CNS

0348934 - ÚEM 2011 RIV US eng J - Journal Article
Bekku, Y. - Vargová, Lýdia - Goto, Y. - Voříšek, Ivan - Dmytrenko, Lesia - Narasaki, M. - Ohtsuka, A. - Fässler, R. - Ninomiya, Y. - Syková, Eva - Oohashi, T.
Bral1: Its Role in Diffusion Barrier Formation and Conduction Velocity in the CNS.
Journal of Neuroscience. Roč. 30, č. 8 (2010), s. 3113-3123. ISSN 0270-6474. E-ISSN 1529-2401
R&D Projects: GA ČR GA309/09/1597
Grant - others:GA MŠk(CZ) 1M0538; GA MZd(CZ) NS9915
Program: 1M
Institutional research plan: CEZ:AV0Z50390512
Keywords : Bral1 * central nervous system * brain development
Subject RIV: FH - Neurology
Impact factor: 7.271, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0348934_01.pdf

Brain-specific hyaluronan-binding link protein, Bral1, colocalizes and forms complexes with negatively charged extracellular matrix (ECM) proteins at the nodes of Ranvier in the myelinated white matter. The study report that the ECM no longer shows a nodal pattern and that CNS nerve conduction is markedly decreased in Bral1-deficient mice and the changes in the extracellular space diffusion parameters, measured by the real-time iontophoretic method and diffusion-weighted magnetic resonance imaging (MRI), suggest a reduction in the diffusion hindrances in the white matter of mutant mice.
Permanent Link: http://hdl.handle.net/11104/0189315