Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits

0347601 - ÚEM 2011 RIV GB eng J - Journal Article
Schwenk, J. - Metz, M. - Zolles, G. - Tureček, Rostislav - Fritzius, T. - Bildl, W. - Tarusawa, E. - Kulik, A. - Unger, A. - Ivankova, K. - Seddik, R. - Tiao, J. Y. - Rajalu, M. - Trojanová, Johana - Rohde, V. - Gassmann, M. - Schulte, U. - Fakler, B. - Bettler, B.
Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits.
Nature. Roč. 465, č. 7295 (2010), s. 231-237. ISSN 0028-0836. E-ISSN 1476-4687
R&D Projects: GA ČR GA309/06/1304
Institutional research plan: CEZ:AV0Z50390512
Keywords : GABA(B) * nhibitor neurotransmitter * receptors
Subject RIV: FH - Neurology
Impact factor: 36.104, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0347601_01.pdf

GABA(B) receptors are the G-protein-coupled receptors for GABA, the main inhibitory neurotransmitter in the brain. We show by functional proteomics that GABA(B) receptors in the brain are high-molecular-mass complexes of GABA(B1), GABA(B2) and members of a subfamily of the KCTD proteins. KCTD proteins associate tightly with the carboxy terminus of GABA(B2) as auxiliary subunits of GABA(B) receptors and determine the pharmacology and kinetics of the receptor response.
Permanent Link: http://hdl.handle.net/11104/0188348