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How to fight with Creutzfeldt-Jakob disease? Reaction of Prion peptides with Quinacrine: Organic and Physical Studies
- 1.0347144 - ÚOCHB 2011 SK eng A - Abstract
Zawada, Zbigniew - Šebestík, Jaroslav - Šafařík, Martin - Březinová, Anna - Krejčiříková, A. - Holada, K. - Hlaváček, Jan - Stibor, Ivan - Bouř, Petr
How to fight with Creutzfeldt-Jakob disease? Reaction of Prion peptides with Quinacrine: Organic and Physical Studies.
29th Conference of Organic Chemists. Advances in Organic Chemistry. Smolenice: -, 2010. s. 102-102.
[Conference of Organic Chemists. Advances in Organic Chemistry /29./. 05.09.2010-09.09.2010, Smolenice]
R&D Projects: GA ČR GA203/07/1517
Institutional research plan: CEZ:AV0Z40550506
Keywords : prions * quinacrine * DFT
Subject RIV: CC - Organic Chemistry
Reaction of quinacrine with prion protein and prion protein derived peptides were studied. Reaction mechanisms was proposed and reaction coordinate was calculated. It was shown that prion peptide thiol groups can be covalentely modified with quinacrine via acridine transfer reaction.
Permanent Link: http://hdl.handle.net/11104/0187986
Number of the records: 1