Distribution of polyethylene wear particles and bone fragments in periprosthetic tissue around total hip joint replacements

0347024 - ÚMCH 2011 RIV GB eng J - Journal Article
Zolotarevova, E. - Entlicher, G. - Pavlova, Ewa - Šlouf, Miroslav - Pokorný, D. - Veselý, F. - Gallo, J. - Sosna, A.
Distribution of polyethylene wear particles and bone fragments in periprosthetic tissue around total hip joint replacements.
Acta Biomaterialia. Roč. 6, č. 9 (2010), s. 3595-3600. ISSN 1742-7061. E-ISSN 1878-7568
R&D Projects: GA MŠMT 2B06096
Institutional research plan: CEZ:AV0Z40500505
Keywords : joint replacement * polyethylene * wear particles distribution
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 4.824, year: 2010

Ultra-high molecular weight polyethylene (UHMWPE) wear particles play a significant role in failures of total joint replacements (TJRs). In this work, we investigated the distribution of these wear particles in periprosthetic tissues obtained from nine revisions of hip TJR. All periprosthetic tissues were combined and mechanically separated into granuloma tissue (containing hard granules visible to the naked eye) and surrounding tissue (without visible granules). Of the total amount of polyethylene particles in the whole granuloma tissue, 72% of particles in the size range 0.1–10 um and 68% of those larger than 10 um were found in granules. Therefore, the formation of granules significantly lowers the effective amount of wear particles available for interaction with reactive cells and seems to be a natural defense mechanism.
Permanent Link: http://hdl.handle.net/11104/0006002