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The preparation of 3-H-labeled Acyclic Nucleoside Phosphonates and Study of their Stability
- 1.0346290 - ÚOCHB 2011 RIV CZ eng J - Journal Article
Elbert, Tomáš - Břehová, Petra - Holý, Antonín
The preparation of 3-H-labeled Acyclic Nucleoside Phosphonates and Study of their Stability.
Collection of Czechoslovak Chemical Communications. Roč. 75, č. 7 (2010), s. 757-766. ISSN 0010-0765
R&D Projects: GA MŠMT 1M0508; GA AV ČR IAA400550801
Institutional research plan: CEZ:AV0Z40550506
Keywords : tritium * 3-H NMR * acyclic nucleotide analogues
Subject RIV: CC - Organic Chemistry
Impact factor: 0.853, year: 2010
9-(2-Phosphonomethoxyethyl)-2,6-diamino-[8-3H]purine, 9-(2-phosphonomethoxyethyl)- [8-3H]guanine and (R)- 9-(2-phosphonomethoxypropyl)-[8-3H]adenine with specific activities of 10.9 Ci/mmol, 7.9 Ci/mmol and 16 Ci/mmol, respectively, were prepared by a catalytic dehalogenation of the corresponding 8-bromo derivatives. The rate of the exchange of the tritium label on C-8 of the purine ring in title compounds with the hydrogen of water under physiological pH at 20 °C was studied using 3H NMR.
Permanent Link: http://hdl.handle.net/11104/0187358
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