Expression and light sensitivity of clock genes Per1 and Per2 and immediate-early gene c-fos within the retina of early postnatal Wistar rats

0345610 - FGÚ 2011 RIV US eng J - Journal Article
Matějů, Kristýna - Sumová, Alena - Bendová, Zdeňka
Expression and light sensitivity of clock genes Per1 and Per2 and immediate-early gene c-fos within the retina of early postnatal Wistar rats.
Journal of Comparative Neurology. Roč. 518, č. 17 (2010), s. 3630-3644. ISSN 0021-9967. E-ISSN 1096-9861
R&D Projects: GA ČR(CZ) GA309/08/0503; GA MŠMT(CZ) LC554
EU Projects: European Commission(XE) 18741 - EUCLOCK
Grant - others:GA ČR(CZ) GD309/08/H079
Institutional research plan: CEZ:AV0Z50110509
Keywords : development * retina * circadian clock
Subject RIV: FH - Neurology
Impact factor: 3.774, year: 2010

The aim of the study was to elucidate whether, when and where the transcripts of the clock genes Per1 and Per2 and the immediate early gene c-fos are spontaneously expressed and/or induced by light in the newborn retina. Endogenous expression of Per1 was detected in the neuroblastic retina, and Per2 expression was detected in the inner part of the neuroblastic retina from birth. Light pulses induced c-fos expression in ganglion cells from postnatal day 1 (P1). Light pulses also induced the expression of Per1 and c-fos in the retinal pigment epithelium until P3, but not afterward. Expression of Per2 was not photoresponsive until P10. The data demonstrate that the rat retina is photosensitive immediately after birth. During early postnatal development, the spatial distribution of spontaneous and light-induced gene expression within the retinal layers changes gradually
Permanent Link: http://hdl.handle.net/11104/0186844