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Inhibition of canonical Wnt signaling promotes gliogenesis in PO-NSCs
- 1.0345341 - BFÚ 2011 RIV US eng J - Journal Article
Kunke, D. - Bryja, Vítězslav - Mygland, L. - Arenas, E. - Krauss, S.
Inhibition of canonical Wnt signaling promotes gliogenesis in PO-NSCs.
Biochemical and Biophysical Research Communications. Roč. 386, č. 4 (2009), s. 628-633. ISSN 0006-291X. E-ISSN 1090-2104
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : differentiation * gliogenesis * neuronal progenitor cells
Subject RIV: BO - Biophysics
Impact factor: 2.548, year: 2009
Writ signaling plays an essential role in the development of mammalian central nervous system. We investigated the impact of activation/inhibition of the Writ signaling pathway on neuronal/glial differentiation in neurospheres derived from neonatal mouse forebrains. For short term alterations, neurospheres were stimulated with recombinant Wnt-3a, Wnt-5a and the Wnt inhibitor Dickkopf-1 (Dkk1).
Permanent Link: http://hdl.handle.net/11104/0186637
Number of the records: 1