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Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase
- 1.0345303 - BFÚ 2011 RIV DE eng J - Journal Article
Ondroušková, E. - Slováčková, J. - Pelková, V. - Procházková, Jiřina - Souček, Karel - Beneš, P. - Šmarda, J.
Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase.
Biological Chemistry. Roč. 390, č. 1 (2009), s. 49-58. ISSN 1431-6730. E-ISSN 1437-4315
R&D Projects: GA ČR(CZ) GA204/07/0834
Grant - others:GA ČR(CZ) GA301/06/0036; GA AV ČR(CZ) IAA501630801
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : Bcl-2 * heavy metals * Jun N-terminal kinase
Subject RIV: BO - Biophysics
Impact factor: 2.732, year: 2009
This study shows that phosphorylation of Bcl-2 can be induced by heavy metals due to activation of the Jun N-terminal kinase pathway that is not linked to the G2/M cell cycle arrest. Furthermore, we demonstrate that hyperphosphorylated Bcl-2 protein is a more potent inhibitor of zinc-induced cell death than its hypophosphorylated mutant form. These data suggest that regulation of Bcl-2 protein function by phosphorylation is an important part of cell responses to stress.
Permanent Link: http://hdl.handle.net/11104/0186611
Number of the records: 1