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Serotonin and its 5-HT2 receptor agonist DOI hydrochloride inhibit the oxidative burst in total leukocytes but not in isolated neutrophils
- 1.0343868 - BFÚ 2011 RIV GB eng J - Journal Article
Prachařová, Lucie - Okénková, Kateřina - Lojek, Antonín - Číž, Milan
Serotonin and its 5-HT2 receptor agonist DOI hydrochloride inhibit the oxidative burst in total leukocytes but not in isolated neutrophils.
Life Sciences. Roč. 86, 13-14 (2010), s. 518-523. ISSN 0024-3205. E-ISSN 1879-0631
R&D Projects: GA ČR(CZ) GA524/07/1511
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : chemiluminescence * oxidative burst * serotonin
Subject RIV: BO - Biophysics
Impact factor: 2.451, year: 2010
It was observed that 5-HT and its 5-HTR2 agonist DOI hydrochloride were able to inhibit the luminol-enhanced CL response in activated rat and human total leukocytes, but not in isolated human PMNL. The interpretation of these results could suggest the indirect involvement of 5-HTR2 expressed not on the neutrophil surface but on the surface of other leukocytes.
Permanent Link: http://hdl.handle.net/11104/0186243
Number of the records: 1