Number of the records: 1
Characterization of purinergic P2X4 receptor channels expressed in anterior pituitary cells
- 1.0343255 - FGÚ 2011 RIV US eng J - Journal Article
Zemková, Hana - Kučka, M. - Li, S. - Gonzales-Iglesias, A. E. - Tomic, M. - Stojilkovic, S. S.
Characterization of purinergic P2X4 receptor channels expressed in anterior pituitary cells.
American Journal of Physiology - Endocrinology And Metabolism. Roč. 298, č. 3 (2010), E664-E651. ISSN 0193-1849. E-ISSN 1522-1555
R&D Projects: GA MŠMT(CZ) LC554; GA ČR(CZ) GA305/07/0681
Institutional research plan: CEZ:AV0Z50110509
Keywords : P2X4 receptor * ATP * pituitary
Subject RIV: ED - Physiology
Impact factor: 4.686, year: 2010
In rat anterior pituitary tissue, mRNA transcripts for the P2X4 subunit are the most abundant and the P2X4 protein is expressed. Extracellular ATP induces ivermectin-sensitive depolarizing current in a majority of thyrotropin-releasing hormone-responsive pituitary cells, and enhances prolactin release. These results indicate that lactotrophs express homomeric and/or heteromeric P2X4 receptors which facilitate hormone secretion
Permanent Link: http://hdl.handle.net/11104/0185773
Number of the records: 1