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Novel analogues of arginine vasopressin containing alpha-2-indanylglycine enantiomers in position 2
- 1.0342519 - ÚOCHB 2011 RIV GB eng J - Journal Article
Kwiatkowska, A. - Sleszyňska, M. - Derdowska, I. - Prahl, A. - Sobolewski, D. - Borovičková, Lenka - Slaninová, Jiřina - Lammek, B.
Novel analogues of arginine vasopressin containing alpha-2-indanylglycine enantiomers in position 2.
Journal of Peptide Science. Roč. 16, č. 1 (2010), s. 15-20. ISSN 1075-2617. E-ISSN 1099-1387
Grant - others:PSCSR(PL) 0230/B/H03/2008/34; PSCSR(PL) 0230/B/H03/2008/35
Institutional research plan: CEZ:AV0Z40550506
Keywords : arginine vasopressin (AVP) analogues * antidiuretic hormone * alpha-2-indanylglycine * conformational restriction
Subject RIV: CC - Organic Chemistry
Impact factor: 1.954, year: 2010
Described synthesis and biological properties of 10 new vasopressin analogues modified at position 2 with alpha-2-indanylglycine or its D-enantiomer. The new analogues were moderate or potent OT antagonists (pA2 values ranging from 7.19 to 7.98) and practically did not interact with V(1a) and V(2) receptors.
Permanent Link: http://hdl.handle.net/11104/0185235
Number of the records: 1