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WT1 expression in peripheral leukocytes of patients with chronic myeloid leukemia serves for the prediction of Imatinib resistance
- 1.0341448 - MBÚ 2010 RIV SK eng J - Journal Article
Otahalová, E. - Ullmannová-Benson, Veronika - Klamová, H. - Haškovec, C.
WT1 expression in peripheral leukocytes of patients with chronic myeloid leukemia serves for the prediction of Imatinib resistance.
Neoplasma. Roč. 56, č. 5 (2009), s. 393-397. ISSN 0028-2685. E-ISSN 1338-4317
Institutional research plan: CEZ:AV0Z50200510
Keywords : Imatinib * drug resistance * cml
Subject RIV: EC - Immunology
Impact factor: 1.192, year: 2009
The determination of patient's resistance to a particular drug contributes to more efficient therapeutical approach. The aim of this study was to evaluate if the responsiveness of Chronic Myeloid Leukemia (CML) patients to Imatinib therapy was predictable from WT1 gene expression in peripheral blood leukocytes. To examine the resistance we implemented an in vitro cultivation of the primary cells of 48 CML patients with Imatinib
Permanent Link: http://hdl.handle.net/11104/0184440
Number of the records: 1