Acute and chronic effects of antidepressants on the G-protein alpha subunit profiles in vitro and in vivo

0341172 - ÚŽFG 2010 RIV SE eng J - Journal Article
Páv, M. - Kovářů, František - Lisá, Věra - Ondráčková-Zeleničková, P. - Fišerová, Anna - Kovářu, H.
Acute and chronic effects of antidepressants on the G-protein alpha subunit profiles in vitro and in vivo.
Neuroendocrinology Letters. Roč. 30, č. 5 (2009), s. 592-598. ISSN 0172-780X. E-ISSN 2354-4716
R&D Projects: GA AV ČR IAA601680801
Institutional research plan: CEZ:AV0Z50450515; CEZ:AV0Z50110509; CEZ:AV0Z50200510
Keywords : C6 glioma cells * C6 astrocytoma cell line * antidepressant
Subject RIV: ED - Physiology
Impact factor: 1.047, year: 2009

Neurochemical studies on the etiopathogenesis of depression are also focusing on the transduction system beyond receptors. Trimeric G-proteins play a crucial role in the transmembrane signalling, signal amplification and intracellular processing. Abnormalities of G-protein levels are observed in subjects with depression, G-protein modulation is considered to play a role in the antidepressant mode of action.
Permanent Link: http://hdl.handle.net/11104/0184244