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Hexabromocyclododecane but not tetrabromobisphenol A
- 1.0341125 - BTÚ 2010 US eng A - Abstract
Dorosh, Andriy - Děd, Lukáš - Elzeinová, Fatima - Pěknicová, Jana
Hexabromocyclododecane but not tetrabromobisphenol A.
Journal of Reproductive Immunology. Elsevier. Roč. 81, č. 2 (2009), s. 153-153. ISSN 0165-0378. E-ISSN 1872-7603.
[7th European Congress on Reproductive Immunology. 17.09.2009-20.09.2009, Marathon]
R&D Projects: GA MŠMT(CZ) 1M06011; GA ČR GD523/08/H064; GA ČR(CZ) GA523/09/1793
Institutional research plan: CEZ:AV0Z50520701
Keywords : estrogen * polybrominated compounds * TFF- 1 * cell proliferation
Subject RIV: DN - Health Impact of the Environment Quality
In this study, we performed MCF-7 proliferation assay and the gene expression analysis of the TFF1 reporter gene. The cell line was exposed to three natural hormones (estrone (E1), 17β-estradiol (E2), and estriol (E3)), one synthetic hormone (17α-ethinylestradiol (EE2)) and two polybrominated compounds (tetrabromobysphenol A (TBBPA) and hexabromocyclododecane (HBCD)). We confirmed the concentration-dependent increase in the cell proliferation and TFF1 gene expression after exposure the MCF-7 cells with estrogen. Further, we found that HBCD but not TBBPA has estrogenic effect on MCF-7 cells in vitro.
Permanent Link: http://hdl.handle.net/11104/0184205
Number of the records: 1