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Functionalizable surface platform with reduced nonspecific protein adsorption from bull blood plasma - Material selection and protein immobilization optimization
- 1.0341080 - ÚFE 2010 RIV GB eng J - Journal Article
Vaisocherová, Hana - Zhang, Z. - Yang, W. - Cao, Z. - Cheng, G. - Taylor, A. D. - Piliarik, Marek - Homola, Jiří - Jiang, S.
Functionalizable surface platform with reduced nonspecific protein adsorption from bull blood plasma - Material selection and protein immobilization optimization.
Biosensors and Bioelectronics. Roč. 24, č. 7 (2009), s. 1924-1930. ISSN 0956-5663. E-ISSN 1873-4235
R&D Projects: GA AV ČR KAN200670701
Institutional research plan: CEZ:AV0Z20670512
Keywords : Zwitterionic poly(carboxybetaine) * Functionalization * Ultra-low fouling
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 5.429, year: 2009
Zwitterionic polymers are investigated as ultra-low fouling and functionalizable coatings for biosensorsand microarrays to enable detections in real-world complex media. The effect of the spacer length between the two charged groups on the nonfouling properties of zwitterionic poly(carboxybetaine acrylamide) (polyCBAA) was studied in blood plasma and serum. A polyCBAA-coated surface was functionalized with antibodies using a simple and fast amino coupling chemistry for direct protein immobilization.
Permanent Link: http://hdl.handle.net/11104/0184178
Number of the records: 1