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Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells
- 1.0340647 - BFÚ 2010 RIV GB eng J - Journal Article
Jendželovský, R. - Mikeš, J. - Koval, J. - Souček, Karel - Procházková, Jiřina - Kello, M. - Sačková, V. - Hofmanová, Jiřina - Kozubík, Alois - Fedoročko, P.
Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells.
Photochemical & Photobiological Sciences. Roč. 8, č. 12 (2009), s. 1716-1723. ISSN 1474-905X. E-ISSN 1474-9092
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : hypericin * photodynamic therapy * ABC transporters
Subject RIV: BO - Biophysics
Impact factor: 2.708, year: 2009
We have investigated the efficiency of a combined modality approach employing 24 h pretreatment of relatively PDT-resistant HT-29 colon adenocarcinoma cells with proadifen followed by HY-PDT. Since significant accumulation of hypericin was found to be a principal factor responsible for ROS induction and therefore higher efficiency of HY-PDT, involvement of ABC transporter system was evaluated.
Permanent Link: http://hdl.handle.net/11104/0183851
Number of the records: 1