Co-transplantation of olfactory ensheathing glia and mesenchymal stromal cells does not have synergistic effects after spinal cord injury in the rat

0340207 - ÚEM 2010 RIV NO eng J - Journal Article
Amemori, Takashi - Jendelová, Pavla - Růžičková, Kateřina - Arboleda Toro, David - Syková, Eva
Co-transplantation of olfactory ensheathing glia and mesenchymal stromal cells does not have synergistic effects after spinal cord injury in the rat.
Cytotherapy. Roč. 12, č. 2 (2010), s. 212-225. ISSN 1465-3249. E-ISSN 1477-2566
R&D Projects: GA AV ČR IAA500390902; GA ČR GA309/06/1246; GA MŠMT(CZ) LC554
Grant - others:GA MŠk.(CZ) 1M0538; GA MZd(CZ) 1A8697
Program: 1M
Institutional research plan: CEZ:AV0Z50390703
Keywords : mesemchymal stromal cells * olfactory ensheathing glia * spinal cord injury
Subject RIV: FH - Neurology
Impact factor: 2.925, year: 2010

Olfactory ensheathing glia (OEG) and mesenchymal stromal cells (MSC) have been investigated as promising candidates for spinal cord repair. In this study, the effect of the transplantation of OEG and/or MSC on behavioral, electrophysiologic and histologic outcomes after SCI was studied. Both OEG and MSC could foster locomotor function by sparing the spinal cord, but their combined advantages provide no added benefit to SCI therapy. We speculate that to maximize the advantageous effects of co-transplantation, direct implantation of OEG into the spinal cord lesion accompanied by intravenous injection of MSC might be more efficacious approach to the co-transplantation of OEG and MSC.
Permanent Link: http://hdl.handle.net/11104/0183498