Number of the records: 1
The effect of flavonoid derivatives on doxorubicin transport and metabolism
- 1.0340042 - ÚMG 2010 RIV GB eng J - Journal Article
Václavíková, R. - Kondrová, E. - Ehrlichová, Marie - Boumendjel, A. - Kovář, Jan - Stopka, Pavel - Souček, P. - Gut, I.
The effect of flavonoid derivatives on doxorubicin transport and metabolism.
Bioorganic & Medicinal Chemistry. Roč. 16, č. 4 (2008), s. 2034-2042. ISSN 0968-0896. E-ISSN 1464-3391
Institutional research plan: CEZ:AV0Z40320502; CEZ:AV0Z50520514
Keywords : Doxorubicin * Quercetin * Flavonoids * P-Glycoprotein
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.075, year: 2008
This study investigated the effect of naturally occurring flavonoids and synthetic aurone derivatives on the formation of cardiotoxic doxorubicinol and transport of doxorubicin in breast cancer cells. Quercetin significantly inhibited the formation of doxorubicinol. Quercetin and aurones did not significantly affect transport of doxorubicin in human resistant breast cancer cells. In conclusion, quercetin should be further tested for its potency to decrease doxorubicin-mediated toxicity.
Permanent Link: http://hdl.handle.net/11104/0183369
Number of the records: 1