High-molecular-weight polymers containing biodegradable disulfide bonds: synthesis and in vitro verification of intracellular degradation

0338553 - ÚMCH 2010 RIV GB eng J - Journal Article
Etrych, Tomáš - Kovář, Lubomír - Šubr, Vladimír - Braunová, Alena - Pechar, Michal - Chytil, Petr - Říhová, Blanka - Ulbrich, Karel
High-molecular-weight polymers containing biodegradable disulfide bonds: synthesis and in vitro verification of intracellular degradation.
Journal of Bioactive and Compatible Polymers. Roč. 25, č. 1 (2010), s. 5-26. ISSN 0883-9115. E-ISSN 1530-8030
R&D Projects: GA AV ČR IAA400500806; GA AV ČR KAN200200651
Institutional research plan: CEZ:AV0Z40500505; CEZ:AV0Z50200510
Keywords : water-soluble polymers * reductive degradation * HPMA copolymers
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 2.610, year: 2010

The synthesis, physico-chemical behavior, and in vitro intracellular degradation of new biodegradable graft, diblock or multiblock polymer carriers that were designed to deliver bioactive compounds by passive tumor targeting were investigated. In all three carrier systems, the single polymers were linked via biodegradable disulfide bonds forming the graft, diblock or multiblock polymers. Here, degradation of the polymers in model buffer solutions mimicking intracellular environment as well as after incubation with EL4 T-cell lymphoma cancer cells were investigated. In both cases, degradation resulted in polymer fragments of molecular weight below the renal threshold.
Permanent Link: http://hdl.handle.net/11104/0005710