In vitro and in vivo studies of the neuroprotective peptide humanin using 125I-radiolabeled humanin derivatives

0338101 - ÚOCHB 2011 CZ eng C - Conference Paper (international conference)
Evangelou, A. - Zikos, C. - Benaki, D. - Pelecanou, M. - Bouziotis, P. - Papadopoulos, M. - Borovičková, Lenka - Veselá, Iva - Elbert, Tomáš - Kunešová, G. - Pirmettis, I. - Paravatou-Petsotas, M. - Slaninová, Jiřina - Livaniou, E.
In vitro and in vivo studies of the neuroprotective peptide humanin using 125I-radiolabeled humanin derivatives.
Biologically Active Peptides. 11th Conference. Praha: Institut of organic Chemistry and Biochemistry ASCR, 2009 - (Slaninová, J.), s. 34-36. Collection Symposium Series, 11. ISBN 978-80-86241-31-9.
[Biologically Active Peptides. Conference /11./. Praha (CZ), 22.04.2009-24.04.2009]
Institutional research plan: CEZ:AV0Z40550506
Keywords : neuroprotective peptides * humanin * 125I-radiolabeled derivatives * in vitro binding
Subject RIV: CC - Organic Chemistry

Four new HN-derivatives were synthesized: Y-PAGASRLLLTGEIDLP (Y-des-Leu-RG-PAGA, 1), Y-PAGASRLLLLTGEIDLP (Y-RG-PAGA, 2), Y-SALLRSIPAPAGASRLLLTGEIDLP (Y-des-Leu-Colivelin, 3), Y-SALLRSIPAPAGASRLLLLTGEIDLP (Y-Colivelin, 4), their neuroprotective action was evaluated in the T-maze test and the most active ones were monoradioiodinated with 125I and the labelled peptides used for binding and biodistribution studies.
Permanent Link: http://hdl.handle.net/11104/0181961