In vitro binding and in vivo biodistribution studies of the neuroprotective peptide humanin using [125I]humanin derivatives

0337442 - ÚOCHB 2010 RIV US eng J - Journal Article
Evangelou, A. - Zikos, C. - Benaki, D. - Pelecanou, M. - Bouziotis, P. - Papadopoulos, M. - Borovičková, Lenka - Veselá, Iva - Elbert, Tomáš - Kunešová, G. - Pirmettis, I. - Paravatou-Petsotas, M. - Slaninová, Jiřina - Livaniou, E.
In vitro binding and in vivo biodistribution studies of the neuroprotective peptide humanin using [125I]humanin derivatives.
Peptides. Roč. 30, č. 12 (2009), s. 2409-2417. ISSN 0196-9781. E-ISSN 1873-5169
R&D Projects: GA MŠMT ME 872
Grant - others:Czech-Greek Joint Research and Technology Programme(GR) 188-gamma
Institutional research plan: CEZ:AV0Z40550506
Keywords : neuroprotective peptides * humanin derivatives * [125I] radiolabeling
Subject RIV: CE - Biochemistry
Impact factor: 2.705, year: 2009

Four new, tyrosine containing humanin derivatives were synthesized, the neuroprotective action was evaluated in the T-maze test and the most active ones were radiolabeled with 125I. Under the experimental conditions used, our data do not confirm the existence of specific binding sites for humanin on the neuronal tissue.
Permanent Link: http://hdl.handle.net/11104/0181434