Number of the records: 1
Mechanistic studies of the modulation of cleavage activity of topoisomerase I by DNA adducts of mono- and bi-functional Pt-II complexes
- 1.0332052 - BFÚ 2010 RIV GB eng J - Journal Article
Malina, Jaroslav - Vrána, Oldřich - Brabec, Viktor
Mechanistic studies of the modulation of cleavage activity of topoisomerase I by DNA adducts of mono- and bi-functional Pt-II complexes.
[Mechanistická studie modulace štěpící aktivity topoisomerázy I vlivem mono- a bifunkčních aduktů platnatých komplexů na DNA.]
Nucleic Acids Research. Roč. 37, č. 16 (2009), s. 5432-5442. ISSN 0305-1048. E-ISSN 1362-4962
R&D Projects: GA MŠMT(CZ) LC06030; GA MŠMT(CZ) ME08017; GA MŠMT(CZ) OC08003; GA AV ČR(CZ) 1QS500040581; GA AV ČR(CZ) KAN200200651; GA AV ČR(CZ) IAA400040803
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : cisplatin * camptothecin * topoisomerase I
Subject RIV: BO - Biophysics
Impact factor: 7.479, year: 2009
DNA adducts of bifunctional antitumor cisplatin or monodentate [PtCl(dien)]Cl (dien = diethylenetriamine) inhibit eukaryotic topoisomerase 1 (top1) action, the adducts of cisplatin being more effective. The presence of camptothecin markedly enhances effects of Pt-DNA adducts on top1 activity depending on the sequence context.
Bifunkční adukty cisplatiny účinněji inhibují aktivitu eukaryontní topoisomerázy 1 (top1) než monofunkční adukty [PtCl(dien)]Cl (dien = diethylenetriamine). Přítomnost camptothecinu zesiluje efekt aduktů platnatých komplexů v závislosti na sekvenci DNA.
Permanent Link: http://hdl.handle.net/11104/0177406
Number of the records: 1