Indapamide-induced prevention of myocardial fibrosis in spontaneous hypertension rats is not nitric oxide-related

0331650 - FGÚ 2010 RIV CZ eng J - Journal Article
Janega, P. - Kojšová, S. - Jendeková, L. - Babál, P. - Pecháňová, Olga
Indapamide-induced prevention of myocardial fibrosis in spontaneous hypertension rats is not nitric oxide-related.
[Indapamidem navozená prevence vzniku srdeční fibrózy u spontánně hypertenzních potkanů není závislá na oxidu dusnatém.]
Physiological Research. Roč. 56, č. 6 (2007), s. 825-828. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MŠMT(CZ) 1M0510
Institutional research plan: CEZ:AV0Z50110509
Keywords : indapamide * myocardial fibrosis * genetic hypertension
Subject RIV: ED - Physiology
Impact factor: 1.505, year: 2007

The effect of thiazide-like diuretic-indapamide on fibrosis development in the left ventricle of young spontaneously hypertensive rats (SHR) was studied in order to assess the involvement of nitric oxide in this process. Indapamide prevented myocardial fibrosis development in SHR, but without affecting collagen type I to type III ratio. Indapamide did not affect NOS activity as well as eNOS and iNOS protein expressions in the left ventricles. Thus indapamide-induced prevention of myocardial fibrosis is not mediated by nitric oxide-related mechanism

Účinky thiazidového diuretika indapamidu na vývoj fibrózy v levé komoře srdeční spontánně hypertenzních potkanů (SHR) byly studovány s cílem objasnit úlohu NO v tomto procesu. Indapamid zabránil vzniku fibrózy u SHR, ale neovlivnil poměr kolagenu I a III. Indapamid také neovlivnil aktivitu NO syntázy ani expresi endoteliální NO syntázy resp. indukovatelné NO syntázy v levé komoře.Proto je zřejmé, že účinky indapamidu nejsou zprostředkovány mechanismem závislým na oxidu dusnatém
Permanent Link: http://hdl.handle.net/11104/0177111