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5-Lipoxygenase inhibitors potentiate 1alpha,25-dihydroxyvitamin D3-induced monocytic differentiation by activating p38 MAPK pathway
- 1.0330952 - BFÚ 2010 RIV NL eng J - Journal Article
Stixová, Lenka - Procházková, Jiřina - Souček, Karel - Hofmanová, Jiřina - Kozubík, Alois
5-Lipoxygenase inhibitors potentiate 1alpha,25-dihydroxyvitamin D3-induced monocytic differentiation by activating p38 MAPK pathway.
[Inhibitory 5-lipoxygenázy posilují monocytární diferenciaci indukovanou 1alfa,25-dihydroxyvitaminem D3 aktivací p38 MAPK dráhy.]
Molecular and Cellular Biochemistry. Roč. 330, 1-2 (2009), s. 229-238. ISSN 0300-8177. E-ISSN 1573-4919
R&D Projects: GA ČR(CZ) GP524/06/P345; GA ČR(CZ) GA301/07/1557; GA AV ČR(CZ) 1QS500040507
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : differentiation * 1alpha,25-dihydroxyvitamin D3 * 5-lipoxygenase inhibitors
Subject RIV: BO - Biophysics
Impact factor: 1.896, year: 2009
The VD3 effects on HL-60 cell differentiation were significantly potentiated by 5-LPO inhibitors MK-886 and AA-861 and were inverted by SB202190, a p38 MAPK inhibitor. These results indicated that p38 MAPK pathway is involved in potentiated monocytic differentiation.
Účinky 1alfa,25-dihydroxyvitaminu D3 (VD3) na diferenciaci buněk HL-60 byly významně posíleny inhibitory 5-LPO MK-886 a AA-861 a byly zvráceny inhibitorem p38 MAPK SB202190. Tyto výsledky ukázaly, že dráha p38 MAPK je zapojená do posílené monocytární diferenciace.
Permanent Link: http://hdl.handle.net/11104/0176608
Number of the records: 1