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Differences in DNA damage and repair produced by systemic, hepatocarcinogenic and sarcomagenic dibenzocarbazole derivatives in a model of rat liver progenitor
- 1.0330473 - ÚEM 2010 RIV NL eng J - Journal Article
Valovičová, Z. - Marvanová, S. - Mészárosová, M. - Strančíková, A. - Trilecová, L. - Milcová, Alena - Líbalová, Helena - Vondráček, J. - Machala, M. - Topinka, Jan - Gábelová, A.
Differences in DNA damage and repair produced by systemic, hepatocarcinogenic and sarcomagenic dibenzocarbazole derivatives in a model of rat liver progenitor.
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. Roč. 665, 1-2 (2009), s. 51-60. ISSN 0027-5107
R&D Projects: GA MŠMT 2B08005; GA MŽP(CZ) SP/1B3/8/08
Institutional research plan: CEZ:AV0Z50390512
Keywords : DNA adducts * DNA strand breaks * oxidative stress
Subject RIV: DN - Health Impact of the Environment Quality
Impact factor: 3.556, year: 2009
The qualitative differences in the DNA damage profiles produced by hepatocarcinogens DBC and DiMeDBC in WB-F344 cells were demonstrated. Different lesions may trigger distinct cellular pathways involved in hepatocarcinogenesis. The low amount of DNA damage, together with an efficient repair, may explain the lack of hepatocarcinogenicity of N-MeDBC.
Permanent Link: http://hdl.handle.net/11104/0176256
Number of the records: 1