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Growth differentiation factor-15 secreted by prostate cancer cells inhibits differentiation of osteoclasts
- 1.0328560 - BFÚ 2010 GB eng A - Abstract
Vaňhara, P. - Lincová, Eva - Souček, Karel - Šmarda, J.
Growth differentiation factor-15 secreted by prostate cancer cells inhibits differentiation of osteoclasts.
[Růstový diferenciační faktor-15 (GDF-15) sekretovaný prostatickými buňkami inhibuje diferenciaci osteoklastů.]
FEBS Journal. Roč. 276, č. 1 (2009), s. 226. ISSN 1742-464X. E-ISSN 1742-4658.
[34th FEBS Congress. 04.07.2009-09.07.2009, Prague]
R&D Projects: GA ČR(CZ) GA204/07/0834
Grant - others:GA ČR(CZ) GA301/09/1115
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : growth-differentiation factor-15 * osteoclasts * differentiation
Subject RIV: BO - Biophysics
Both purified GDF-15 and unpurified product secreted by prostate cancer cells strongly intereferes with differentiation of osteoclasts by inhibiting expression and activity of NFkappaB and c-Fos transcription factors.
Cytokin GDF-15 v purifikované formě i vyprodukovaný nádorovými buňkami prostaty významně inhibuje diferenciace osteoklastů inhibicí exprese a aktivity transkripčních faktorů NFkappaB a c-Fos.
Permanent Link: http://hdl.handle.net/11104/0174851
Number of the records: 1