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Nitric oxide signaling pathways
- 1.0324219 - FGÚ 2009 RIV SK eng M - Monography Chapter
Balková, P. - Neckář, Jan - Milerová, Marie - Novák, F. - Kolář, František - Nováková, O.
Effects of N-acetylcysteine on the expression and activity of MnSOD in chronically hypoxic and normoxic rat hearts.
[Vliv N-acetylcysteinu na expresi a aktivitu MnSOD v srdci normoxických a chronicky hypoxických potkanů.]
Nitric oxide signaling pathways. Bratislava: Advent-Orion, 2007 - (Pecháňová, O.), s. 46-56. ISBN 978-80-8071-094-1
R&D Projects: GA ČR(CZ) GA305/07/0875
Institutional research plan: CEZ:AV0Z50110509
Keywords : chronic hypoxia * oxidative stress * heart
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
The aim of this study was to determine whether the inhibition of oxidative stress by N-acetylcysteine in rats during adaptation to chronic hypoxic affects the expression and activity of MnSOD. Our results showed that the induction of MnSOD, which is mediated by chronic hypoxic-induced increased oxidative, may involved in its protective effects
Cílem studie bylo zjistit, jak ovlivní chronické podávání N-acetylcysteinu expresi a aktivitu MnSOD v normoxickém a chronicky hypoxickém myokardu. Výsledky studie ukázaly, že zvýšená exprese a aktivita MnSOD v chronicky hypoxickém myokardu může souviset se zvýšenou ischemickou tolerancí těchto srdcí
Permanent Link: http://hdl.handle.net/11104/0171971
Number of the records: 1