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The effect of low dose of vinclozolin on reproductive tract development in CD1 outbred mice
- 1.0323319 - BTÚ 2011 CZ eng K - Conference Paper (Czech conference)
Pěknicová, Jana - Elzeinová, Fatima - Nováková, Vendula - Buckiová, Daniela - Kubátová, Alena
The effect of low dose of vinclozolin on reproductive tract development in CD1 outbred mice.
European Andrology - 3. český a mezinárodní andrologický kongres. Praha: Androgeos, 2008 - (Heráček, J.), s. 48. ISSN 1802-4793.
[3. český a mezinárodní andrologický kongres. Štiřín (CZ), 13.06.2008-15.06.2008]
R&D Projects: GA MŠMT(CZ) 1M0611; GA MŠMT(CZ) 2B06151
Institutional research plan: CEZ:AV0Z50520701
Keywords : vinclozolin * spermatozoa
Subject RIV: DN - Health Impact of the Environment Quality
The effect of a low dose of vinclozolin within the development of the reproductive tract during gestation (VIN-GD 15-22) and puberty (VIN-PND 23-44) in CD1 mice was tested. We found a decrease in the anogenital distance, prostate weight and pathology of testes in both experimental groups. Sperm counts decreased to 46% (VIN-GD) and to 81% (VIN-PND), and also the acrosomal state (evaluated by antiacrosomal antibody) decreased in both groups to 89% in comparison to the control group (100%). Sperm head abnormalities increased by approximately 18% and 13%, respectively. In this connection, the expression of some genes was changed (arosome-related gene (Acr), apoptosis related genes (p53, p21)). In conclusion, a low dose of vinclozolin affected the reproductive tract, sperm parameters and expression of selected genes in both experimental groups.
Permanent Link: http://hdl.handle.net/11104/0171316
Number of the records: 1