Effect of endocrine disruptors on mammalian fertlity

0323287 - BTÚ 2011 RIV RU eng C - Conference Paper (international conference)
Pěknicová, Jana - Nováková, Vendula - Buckiová, Daniela - Boubelík, Michael
Effect of endocrine disruptors on mammalian fertlity.
Book of abstract. Moskva: Medi Expo, 2008, s. 60-61. ISBN 978-5-94943-043-9.
[European Congress of Reproductive Immunology /6./. Moskva (RU), 30.06.2008-03.07.2008]
R&D Projects: GA MŠMT(CZ) 1M06011; GA MŠMT(CZ) 2B06151; GA MŠMT(CZ) OE 211
Institutional research plan: CEZ:AV0Z50520701; CEZ:AV0Z5039906; CEZ:AV0Z5052915
Keywords : endocrine disruptor * mammalian fertility * spermatozoa
Subject RIV: DN - Health Impact of the Environment Quality

Endocrine system is one of the most important regulatory systems in the mammalian body. The endocrine disruptors (ED) can disrupt the function of the endocrine system but their activity is not a result of the physiological regulation. The effect of low dose of selected ED, bisphenol-A (BPA), p-nonylphenol (NP), diethylstilbestrol (DES), genistein (GEN), resveratrol (RES)), hormone (17α-ethynylestradiol (EE2)) and polybrominated compound (tetrabromobisphenol A (TBBPA)) within development of reproductive tract in outbred CD1 mice was tested. BPA and NP had a negative effect on reproductive organs morphology and mouse spermatozoa. The fertility of mice exposed to DES was disrupted. Contrary to that, treatment by GEN and RES had no effect on the fertility of mice but had some effect on their reproductive parameters except for sperm integrity. Synthetic hormone (EE2) and polybrominated compound (TBBPA) also affected on the organ weight, reproductive parameters and sperm quality.
Permanent Link: http://hdl.handle.net/11104/0171290