Oligopeptides as targeting structures in cancer therapy

0323162 - ÚMCH 2009 RIV NL eng J - Journal Article
Pechar, Michal - Ulbrich, Karel - Etrych, Tomáš - Fabra, A. - Stevenson, M. - Seymour, L.
Oligopeptides as targeting structures in cancer therapy.
[Oligopeptidy jako směrující struktury v nádorové terapii.]
Journal of Controlled Release. Roč. 101, 1-3 (2005), s. 376-379. ISSN 0168-3659. E-ISSN 1873-4995.
[European Symposium on Controlled Drug Delivery /8./. Noordwijk, 07.04.2004-09.04.2004]
Institutional research plan: CEZ:AV0Z40500505
Keywords : oligopeptide targeting * HPMA * prostate cancer
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 3.696, year: 2005

A laminin derived targeting oligopeptide sequence YESIGVAVS was covalently linked to N-(2-hydroxypropyl)methacrylamide (HPMA) based copolymers. Two peptides derived from gonadotropin releasing hormone (GnRH) were also conjugated to HPMA copolymers and used for modification of adenoviral gene delivery vectors. The influence of the polymer coating with and without the targeting peptide on the expression of reporter genes was investigated.

Oligopeptid YESIGVAVS odvozený od lamininu byl kovalentně navázán na kopolymery na bázi N-(2-hydroxypropyl)methakrylamidu (HPMA) Dva peptidy odvozené od gonadotropin uvolňujícího hormonu (GnRH) byly také navázány na HPMA kopolymery a použity pro modifikaci adenovirových vektorů pro dopravu genů. Byl studován vliv polymerního obalu se směrujícími peptidy i bez nich na expresi modelového genu.
Permanent Link: http://hdl.handle.net/11104/0171211